2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-138351
    Propargyl-PEG4-thioacetyl
    Propargyl-PEG4-thioacetyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-thioacetyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-thioacetyl
  • HY-140198
    Amino-PEG20-Boc
    Amino-PEG20-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG20-Boc
  • HY-140552
    N-(Azido-PEG3)-NH-PEG3-acid 2183440-72-2
    N-(Azido-PEG3)-NH-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-NH-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-NH-PEG3-acid
  • HY-132096
    Azido-PEG4-acyl chloride
    Azido-PEG4-acyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-acyl chloride is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-acyl chloride
  • HY-132024
    Bromo-PEG4-MS 2167807-41-0
    Bromo-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG4-MS
  • HY-140720
    Mal-PEG-mal (MW 3400)
    Mal-PEG-mal (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG-mal (MW 3400)
  • HY-141228
    THP-PEG8-Tos 669556-37-0
    THP-PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG8-Tos
  • HY-130879
    HS-PEG5-CH2CH2N3 1449390-11-7
    HS-PEG5-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. HS-PEG5-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    HS-PEG5-CH2CH2N3
  • HY-W190843
    Bromo-PEG2-acetic acid 2409962-85-0
    Bromo-PEG2-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG2-acetic acid
  • HY-140726
    Boc-NH-PEG-amine (MW 3400)
    Boc-NH-PEG-amine (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG-amine (MW 3400)
  • HY-133269
    m-PEG11-SH
    m-PEG11-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG11-SH
  • HY-135179
    Biotin-PEG3-alcohol 289714-02-9
    Biotin-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Biotin-PEG3-alcohol
  • HY-130861
    Mal-NH-PEG4-CH2CH2COOPFP ester 1347750-84-8
    Mal-NH-PEG4-CH2CH2COOPFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-NH-PEG4-CH2CH2COOPFP ester
  • HY-140866
    N-(Azido-PEG4)-N-bis(PEG4-NHS ester) 2353409-90-0
    N-(Azido-PEG4)-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG4)-N-bis(PEG4-NHS ester) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG4)-N-bis(PEG4-NHS ester)
  • HY-140801
    Azido-PEG10-alcohol 877239-09-3
    Azido-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG10-alcohol
  • HY-138481
    Boc-PEG4-methyl propionate 2100306-74-7
    Boc-PEG4-methyl propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-PEG4-methyl propionate
  • HY-134730
    N-Acetylpyrrolidine-PEG2-Br
    N-Acetylpyrrolidine-PEG2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Acetylpyrrolidine-PEG2-Br
  • HY-140794
    Azido-PEG3-C-Boc 172531-36-1
    Azido-PEG3-C-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-C-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-C-Boc
  • HY-132020
    Tos-PEG2-THP 69502-32-5
    Tos-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG2-THP
  • HY-125888
    Boc-NH-C6-amido-C4-acid 10436-21-2
    Boc-NH-C6-amido-C4-acid (PROTAC Linker 32) is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-C6-amido-C4-acid
PROTAC Linkers Isoform Comparison

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